Travelers' diarrhea is one of the most common health problems that afflict individuals from developing countries visiting less affluent regions of the world. Bacterial enteropathogens, particularly diarrheagenic Escherichia coli are the most common agents with a minority of cases due to the protozoan pathogens Cryptosporidium and Giardia or viruses such as norovirus. Although travelers' are aware of risk factors, they rarely exercise dietary precautions aimed at prevention. Fluoroquionoles, azithromycin, and rifaximin, a nonabsorbable antibiotic can decrease duration of illness. Antibiotic prophylaxis is effective and of use in selected circumstances.