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Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e31829455b5
ONLINE ARTICLES: Original Articles

Primary Sclerosing Cholangitis and Its Relationship to the Colon in a Black Cohort of Inflammatory Bowel Disease Patients

Koczka, Charles P. MD*,†; Geraldino-Pardilla, Laura B. MD; Lawlor, Garrett MD

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Abstract

Background:

Recent studies have identified subgroups of inflammatory bowel disease (IBD) patients at increased likelihood for developing primary sclerosing cholangitis (PSC). Most studies look at predominantly white populations.

Goals:

The aim of our study was to determine the characteristics of PSC in a black cohort of patients and its relationship to disease location in IBD.

Study:

A retrospective analysis was performed on IBD patients over the age of 18 years.

Results:

Of the 209 black patients identified as having IBD, 7 (3.5%) had a concomitant diagnosis of PSC; 5/138 (3.6%) ulcerative colitis (UC) patients, and 2/71 (2.8%) Crohn’s disease patients (CD). Numerically, more males developed PSC in both the UC and CD subgroups. Age at diagnosis of IBD tended to be younger among PSC cohorts. All PSC-UC patients had pancolitis (P<0.0001), and all PSC-CD patients had a colonic component to their disease. In the UC cohort, PSC patients were statistically more likely to be on immunosuppressive therapy (P<0.0001).

Conclusions:

With greater research, physicians will better recognize IBD phenotypes at highest risk of PSC and hopefully identify complications of PSC, including cholangiocarcinoma.

Copyright © 2013 by Lippincott Williams & Wilkins

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