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Primary Sclerosing Cholangitis and Its Relationship to the Colon in a Black Cohort of Inflammatory Bowel Disease Patients

Koczka, Charles P. MD*,†; Geraldino-Pardilla, Laura B. MD; Lawlor, Garrett MD

Journal of Clinical Gastroenterology: February 2014 - Volume 48 - Issue 2 - p e19–e21
doi: 10.1097/MCG.0b013e31829455b5
ONLINE ARTICLES: Original Articles

Background: Recent studies have identified subgroups of inflammatory bowel disease (IBD) patients at increased likelihood for developing primary sclerosing cholangitis (PSC). Most studies look at predominantly white populations.

Goals: The aim of our study was to determine the characteristics of PSC in a black cohort of patients and its relationship to disease location in IBD.

Study: A retrospective analysis was performed on IBD patients over the age of 18 years.

Results: Of the 209 black patients identified as having IBD, 7 (3.5%) had a concomitant diagnosis of PSC; 5/138 (3.6%) ulcerative colitis (UC) patients, and 2/71 (2.8%) Crohn’s disease patients (CD). Numerically, more males developed PSC in both the UC and CD subgroups. Age at diagnosis of IBD tended to be younger among PSC cohorts. All PSC-UC patients had pancolitis (P<0.0001), and all PSC-CD patients had a colonic component to their disease. In the UC cohort, PSC patients were statistically more likely to be on immunosuppressive therapy (P<0.0001).

Conclusions: With greater research, physicians will better recognize IBD phenotypes at highest risk of PSC and hopefully identify complications of PSC, including cholangiocarcinoma.

*Department of Gastroenterology, SUNY Downstate Medical Center

Department of Gastroenterology, Brooklyn Campus of the VA NY Harbor Healthcare System, Brooklyn

Department of Rheumatology, Columbia Presbyterian Medical Center, New York, NY

The authors declare that they have nothing to disclose.

Reprints: Charles P. Koczka, MD, 450 Clarkson Avenue, Brooklyn, NY 11203 (e-mail: charles.koczka@downstate.edu).

Received December 11, 2012

Accepted March 25, 2013

© 2014 by Lippincott Williams & Wilkins