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Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e31828f4bc9
ONLINE ARTICLES: Original Articles

Prevalence and Risk Factors of Functional Dyspepsia: A Nationwide Multicenter Prospective Study in Korea

Kim, Sung Eun MD*; Park, Hyun Kyung MD*; Kim, Nayoung MD, PhD*; Joo, Young-Eun MD; Baik, Gwang-Ho MD; Shin, Jeong Eun MD§; Seo, Geom Seog MD; Kim, Gwang Ha MD; Kim, Heung-Up MD#; Kim, Hyun Young MD*; Kim, Seon Mie MD*; Seo, Ji-Hyun MD*; Park, Eun-Ha MD*; Cho, Sung-Il MD**

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Abstract

Goals: To evaluate the prevalence of functional dyspepsia (FD) and its risk factors.

Background: FD is a common disorder, but its negative influences greatly affect the quality of life. The predictive factors of FD are still ambiguous.

Study: A total of 3399 participants underwent screening gastroscopy at one of 7 nationwide health care centers in Korea and who completed a questionnaire. Atrophic gastritis was defined by gastroscopy. Serologic Helicobacter pylori immunoglobulin G antibody was measured by enzyme-linked immunosorbent assay.

Results: Of the 3399 participants who did not have organic diseases, 694 (20.4%) had dyspeptic symptoms such as epigastric pain/soreness or postprandial discomfort. Among the 694 participants, atrophic gastritis and positive H. pylori serology were found in 282 (40.6%) and 422 (60.8%), respectively; these proportions were not different from the remaining asymptomatic subjects. Multivariate analysis showed that having relatives with gastric cancer [odds ratio (OR), 1.35; 95% confidence interval (CI), 1.01-1.81], education below college (OR, 1.32; 95% CI, 1.06-1.64), and high-salt diet (OR, 1.33; 95% CI, 1.05-1.68) were associated with FD symptoms.

Conclusions: FD symptoms were frequently found in the health check-up subjects. Relatives of gastric cancer, education below college, and high-salt diet were risk factors of FD, suggesting that FD is a multifactorial disease.

© 2014 by Lippincott Williams & Wilkins

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