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Various Predictors of Sustained Virologic Response in Different Age Groups of Patients With Genotype-1 Chronic Hepatitis C

Lin, Chun-Yen MD, PhD*,†; Sheen, I-Shyan MD*,†; Chen, Ji-Yih MD†,‡; Huang, Chang-Wen MSc*; Huang, Chien-Hao MD*; Jeng, Wen-Juei MD*; Chen, Wei-Ting MD*

Journal of Clinical Gastroenterology: October 2013 - Volume 47 - Issue 9 - p 794–799
doi: 10.1097/MCG.0b013e31829d2064
LIVER, PANCREAS AND BILIARY TRACT: Original Articles

Background: Age is one of the sustained virologic response (SVR) predictors for genotype-1 chronic hepatitis C patients treated with pegylated interferon-α/ribavirin. However, variation of SVR predictors in different age groups was not explored before. We therefore conducted this study for investigating this issue.

Methods: We retrospectively analyzed 265 genotype-1 chronic hepatitis C patients who received pegylated interferon-α/ribavirin treatment. These patients were divided into 3 age groups. Clinical parameters including the genotype of rs12979860 were analyzed.

Results: SVR rate was highest in patients younger than 45 years and lowest in patients older than 65 years even through propensity score matching analysis. As for rapid virologic response (RVR) predictors, genotype of rs12979860 was the predictor for the patients younger than 45 years and patients aged between 45 and 65 years, but no RVR predictor was found for patients older than 65 years. As for the SVR predictors, HbA1c, baseline viral load, and RVR but not genotype of rs12979860 were the predictors in patients younger than 45 years. For patients between 45 and 65 years, the predictors for SVR were liver fibrosis, genotype of rs12979860, and RVR. For patients older than 65 years, RVR was the only predictor for SVR.

Conclusions: SVR predictors are various in different age groups. RVR is the SVR predictor for all age groups, but the genotype of rs12979860 is the SVR predictor only for patients with age between 45 and 65 years but not younger or older patients.

Departments of *Gastroenterology and Hepatology

Rheumatology, Allergy and Immunology, Linkou Medical Center, Chang Gung Memorial Hospital

School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan

Supported by Chang-Gung Medical Research Program Grants (CMRPG) 371541, 371542, 371543, and 390962 from Chang Gung Memorial Hospital.

C-Y.L., J-Y.C., and I-S.S. conceived, designed, and performed the experiments. C-W.H. analyzed the data, and C-Y.L. and I-S.S. prepared the manuscript. C-H.H., W-J.J., and W-T.C. contributed reagents/materials/analysis tools.

The authors declare that they have nothing to disclose.

Reprints: Chun-Yen Lin, MD, PhD, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center; College of Medicine, Chang Gung University, No. 5, Fushin Street, Kweishan, Taoyuan, Taiwan 333 (e-mail: chunyenlin@gmail.com).

Received September 10, 2012

Accepted May 17, 2013

© 2013 by Lippincott Williams & Wilkins