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Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma

Tabata, Chiharu MD, PhD*; Kanemura, Shingo MD*; Tabata, Rie MD, PhD; Masachika, Eriko MD*; Shibata, Eisuke MD*; Otsuki, Tai-Ichiro MD*; Nishizaki, Tomoyuki MD, PhD; Nakano, Takashi MD, PhD*

Journal of Clinical Gastroenterology: September 2013 - Volume 47 - Issue 8 - p 684–688
doi: 10.1097/MCG.0b013e318297fa65
ALIMENTARY TRACT: Original Articles

Background: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, early diagnosis of DMPM is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. DMPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells, similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.

Study: The serum concentrations of HMGB1 were measured in 13 DMPM patients and 45 individuals with benign asbestos-related diseases.

Result: We demonstrated that the patients with DMPM had significantly higher serum levels of HMGB1 compared with the population who had been exposed to asbestos but did not develop DMPM.

Conclusion: Our data suggest that serum HMGB1 concentration is a useful serum marker for DMPM.

Department of *Internal Medicine, Division of Respiratory Medicine

Department of Physiology, Division of Bioinformation, Hyogo College of Medicine

Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan

C.T. and S.K. contributed equally.

C.T.: designed the research, performed the research, collected data, analyzed and interpreted data, performed statistical analysis, and wrote the manuscript. R.T.: designed the research, performed the research, analyzed and interpreted data, and wrote the manuscript. T. Nakano: designed the research. T. Nishizaki: collected data. S.K.: performed the research. E.S., E.M., and T.-I.O.: collected data.

Supported by Grants from KAKENHI, a Grant-in-Aid for Scientific Research (C) (23591167) and Health Labour Sciences Research Grant.

The authors declare that they have nothing to disclose.

Reprints: Chiharu Tabata, MD, PhD, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan (e-mail:

Received June 30, 2012

Accepted April 18, 2013

© 2013 by Lippincott Williams & Wilkins