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Prognostic Characteristics of Gastrointestinal Tract NK/T-Cell Lymphoma: An Analysis of 47 Patients in China

Jiang, Ming MD*; Chen, Xinchuan MD; Yi, Zhihui MD; Zhang, Xue MD*; Zhang, Bo MD*; Luo, Feng MD*; Jiang, Yu MD*; Zou, Liqun MD*,‡

Journal of Clinical Gastroenterology: September 2013 - Volume 47 - Issue 8 - p e74–e79
doi: 10.1097/MCG.0b013e31829e444f
ONLINE ARTICLE: Original Article

Background: The gastrointestinal tract is the most common primary site of extranodal lymphomas, whereas gastrointestinal natural killer/T-cell (GINKT) lymphomas are relatively rare. To date, neither the prognostic characteristics nor the clinical features or optimal therapeutic approach for GINKT has yet been defined.

Patients and Methods: In this study, a retrospective analysis was carried out on clinical data obtained from 47 patients diagnosed with GINKT lymphoma between May 1999 and August 2011 at West China Hospital.

Results: Patients had a median age of 37 years. Thirty-five of the patients were men (74.5%). The common clinical manifestations included fever (78.7%) and abdominal pain (76.6%). Seventeen patients had intestinal perforation (36.2%). All patients showed ulcerative lesions; the most common site of involvement was the colon (27/47; 57.4%), followed by the jejunoileum and ileocecum (14/47; 29.8%). The median survival period was 2.83 (95% confidence interval, 0.27-29) months. Age, perforation, B syndrome, staging according to Lugano system, and surgery were independent prognostic risk factors for GINKT lymphoma.

Conclusions: This study concluded that GINKT lymphoma is prone to perforation, hemorrhage, and other complications; moreover, the prognosis is very poor. The Lugano staging is a relatively suitable staging system. Surgery before perforation is a key therapy factor that affected prognosis. Although the roles played by chemotherapy and radiotherapy are unclear, combination therapy is necessary.

*Medical Oncology of Cancer Center, State Key Laboratory of Biotherapy

Departments of Hematology

Gastroenterology, West China Hospital, Sichuan University, Chengdu, P.R. China

M.J., X.C., and Z.Y. contributed equally.

The authors declare that they have nothing to disclose.

Reprints: Liqun Zou, MD, No. 37#, Guoxue Xiang, Wuhou District, Chengdu 610041, Sichuan, P.R. China (e-mail: zliqun@hotmail.com).

Received June 25, 2012

Accepted May 27, 2013

© 2013 by Lippincott Williams & Wilkins