Skip Navigation LinksHome > August 2013 - Volume 47 - Issue 7 > Role of Interleukin 28B-related Gene Polymorphisms in Chroni...
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e3182896abf
LIVER, PANCREAS AND BILIARY TRACT: Original Articles

Role of Interleukin 28B-related Gene Polymorphisms in Chronic Hepatitis C and the Response to Antiviral Therapy in Koreans

Jung, Young Kul MD, PhD*; Kim, Ji Hoon MD, PhD; Ahn, Sung-Min MD, PhD; Yang, Jae Won BSc§; Park, Sang Jin MSc, PhD§; Kim, Jong Woo PhD§; Yeon, Jong Eun MD, PhD; Kwon, Oh Sang MD, PhD*; Kim, Yun Soo MD, PhD*; Choi, Duck Joo MD, PhD*; Kim, Ju Hyun MD, PhD*; Byun, Kwan Soo MD, PhD

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Abstract

Background: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population.

Methods: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin.

Results: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ 2=0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR.

Conclusions: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.

© 2013 by Lippincott Williams & Wilkins

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