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MiraLAX-Gatorade Bowel Prep Versus GoLytely Before Screening Colonoscopy: An Endoscopic Database Study in a Community Hospital

Shieh, Frederick K. MD*,†; Gunaratnam, Naresh MD; Mohamud, Sagal O. BSc; Schoenfeld, Philip MD, MSc§,∥

doi: 10.1097/MCG.0b013e3182617bfb
ONLINE ARTICLES: Original Articles

Background: Polyethylene glycol-3350 without electrolytes (MiraLAX; Schering-Plough Healthcare Products Inc.)+a carbohydrate-electrolyte solution (Gatorade; PepsiCo Inc.)+bisacodyl is frequently used for bowel cleansing, although limited data quantifies its efficacy and safety. No prior studies have assessed this in a community setting or with PM-only dosing, which is still used frequently.

Aim: To compare the frequency of excellent/good/fair/poor bowel cleansing with PM-only dosing of MiraLAX-Gatorade-bisacodyl versus 4-liter GoLytely.

Methods: This is a retrospective endoscopic database analysis of 50 years and older average-risk individuals with a normal screening colonoscopy at a community hospital and ambulatory endoscopy center. Data were extracted for the last 4 months when 4-liter GoLytely was the preferred bowel purgative and the first 4 months when 238-g MiraLAX in 64-ounce Gatorade and four 5-mg bisacodyl tablets became the preferred purgative. All patients used PM-only dosing of bowel purgative.

Results: A total of 778 subjects [GoLytely (n=395) vs. MiraLAX+Gatorade+bisacodyl (n=383)] were identified. Patients who took the MiraLAX bowel preparation were more likely to achieve an excellent/good bowel cleansing compared with patients taking the GoLytely preparation (93.3% vs. 89.3%, respectively; P=0.048). However, when only American Society of Anesthesiology (ASA) class I patients are studied, there was no difference in frequency of excellent/good bowel cleansing (91.1% vs 93.6%, respectively; P=0.498). No serious adverse events were identified. An excellent/good bowel cleansing was strongly associated with a recommendation for repeat colonoscopy in 10 years compared with patients with a fair cleansing (odds ratio=28.01; 95% confidence interval, 13.96-56.19).

Conclusions: The MiraLAX+Gatorade+bisacodyl combination produces similar rates of excellent/good bowel cleansing as compared with GoLytely in most average-risk individuals undergoing colonoscopy for colorectal screening in a community setting.

*Department of Internal Medicine

Division of Gastroenterology, University of Michigan School of Medicine

Huron Gastroenterology Associates

§Veterans Affairs Center for Clinical Management Research, Ann Arbor, MI

Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT

P.S. is supported by a K24 Mid-Career Investigator Award in Patient Oriented Research, 1K24DK084208 NIDDK, NIH.

The authors declare that they have nothing to disclose.

Reprints: Philip S. Schoenfeld, MD, Veterans Affairs Center for Clinical Management Research, 111-D, 2215 Fuller Road, Ann Arbor, MI 48105 (e-mail: pschoenf@umich.edu).

Received January 1, 2012

Accepted May 25, 2012

© 2012 Lippincott Williams & Wilkins, Inc.