Skip Navigation LinksHome > November/December 2012 - Volume 46 - Issue 10 > Increased Incidence of Gastric Cancer in Renal Transplant Re...
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e31825c0b3a
ONLINE ARTICLES: Original Articles

Increased Incidence of Gastric Cancer in Renal Transplant Recipients

Park, Jae Myung MD*; Choi, Myung-Gyu MD*; Yang, Chul Woo MD*; Jung, Chan Kwon MD; Lee, Suk Kyeong PhD; Yoon, A-ran MSc; Kim, Yong Soo MD*; Chung, In-Sik MD*

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Abstract

Objective: The risk of malignancy after transplantation is regarded to be higher than in the general population. The aim of this study was to evaluate the frequency of gastric cancer in renal transplant recipients.

Methods: A total of 820 renal transplantation recipients were invited for gastric cancer screening. Frequencies of gastric cancer in this cohort and in 10,080 asymptomatic subjects were compared. Cancer specimens were examined for Epstein-Barr virus by in situ hybridization.

Results: A total of 509 recipients (mean age, 48.1±10.7 y; men, 56.8%) participated. Fifteen (2.9%) and 10 (0.1%) cases of adenocarcinoma were identified among recipients and controls, respectively (P<0.001; odds ratio, 30.58). Early gastric cancer was detected in 9 of the 15 recipients, and 4 of the 9 were treated by endoscopic resection. Recipient age was found to be a significant factor of gastric cancer development. In cancer tissues, Epstein-Barr virus was detected in 5 (33.3%) renal recipients and in 1 (10%) of the controls, respectively.

Conclusions: The frequency of gastric cancer was found to be higher in renal recipients than in controls. Gastric cancer screening should be considered after transplantation, because it would provide cure by minimally invasive treatment.

© 2012 Lippincott Williams & Wilkins, Inc.

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