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Association Between Metabolic Syndrome and Helicobacter pylori Infection Diagnosed by Histologic Status and Serological Status

Shin, Dong Wook MD, MBA*; Kwon, Hyuk Tae MD, MPH; Kang, Jung Min MD*; Park, Jin Ho MD, MPH, PhD*,†; Choi, Ho Chun MD*; Park, Min Seon MD, PhD*; Park, Sang Min MD, MPH, PhD*; Son, Ki Young MD, MPH*; Cho, BeLong MD, MPH, PhD*,†

doi: 10.1097/MCG.0b013e3182522477
ALIMENTARY TRACT: Original Articles

Goals: We aimed to simultaneously evaluate the association between metabolic syndrome and Helicobacter pylori (HP) infection diagnosed histologically and serologically in a large number of healthy Korean adults.

Background: Serological positivity for HP does not necessarily indicate current infection. No study to date has compared the association between metabolic syndrome and HP infection diagnosed by histologic and serological status.

Study: HP status was ascertained histologically and serologically in healthy Korean adults who underwent comprehensive health screening in a private health screening center in Korea. Metabolic syndrome was defined according to the International Diabetes Federation definition. Multivariate logistic analyses were performed, after adjusting for potential confounders, including age, sex, smoking, alcohol consumption, and income level.

Results: A total of 5889 subjects were included in the analysis. The metabolic syndrome was more strongly associated with histologic positivity for HP [adjusted odds ratio (aOR)=1.26; 95% confidence interval (CI), 1.08-1.48] than serologic positivity (aOR=1.12, 95% CI, 0.95-1.32), after adjusting for age, sex, smoking status, alcohol consumption, and economic status.

Conclusions: The stronger association between metabolic syndrome and histologic positivity than serological positivity suggests that the effects of HP infection on the pathogenesis of cardiometabolic outcomes may be reversible. Further prospective studies are needed.

*Department of Family Medicine, Health Promotion Center

Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea

Partly supported by Grant No. 04-2010-0420100960 from the Seoul National University Hospital Research Fund.

The authors declare that they have nothing to disclose.

Reprints: BeLong Cho, MD, MPH, PhD, Department of Family Medicine, Health Promotion Center, Seoul National University Hospital, 101 Daehak-ro, Jongno-Gu, Seoul 110-744, South Korea (e-mail: belong@snu.ac.kr).

Received September 29, 2011

Accepted February 24, 2012

© 2012 Lippincott Williams & Wilkins, Inc.