We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors.
*Departments of Respiratory Medicine
†Pharmacology and Toxicology, University Hospital of Reims
‡Immunology and Microbiology Unit
§INSERM UMRS 903, University of Reims, Reims, France
The authors declare that they have nothing to disclose.
Reprints: Sandra Dury, MD, Department of Respiratory Medicine; Hôpital Maison Blanche—University Hospital of Reims; 45, rue de Cognacq-Jay, 51 100 Reims, France (e-mail: firstname.lastname@example.org).