Skip Navigation LinksHome > November/December 2012 - Volume 46 - Issue 10 > Agranulocytosis Induced by Proton Pump Inhibitors
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e318236f18a
Case Reports

Agranulocytosis Induced by Proton Pump Inhibitors

Dury, Sandra MD*; Nardi, Julie MD*; Gozalo, Claire MD; Lebargy, François MD, PhD*,‡; Deslee, Gaëtan MD, PhD*,§

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Abstract

We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors.

© 2012 Lippincott Williams & Wilkins, Inc.

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