Skip Navigation LinksHome > September 2011 - Volume 45 - Issue 8 > A Randomized, Double-blind, Placebo-controlled Multicenter T...
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e318204593e
ALIMENTARY TRACT: Original Articles

A Randomized, Double-blind, Placebo-controlled Multicenter Trial of Saccharomyces boulardii in Irritable Bowel Syndrome: Effect on Quality of Life

Choi, Chang Hwan MD, PhD*; Jo, Sun Young MD*; Park, Hyo Jin MD, PhD; Chang, Sae Kyung MD, PhD*; Byeon, Jeong-Sik MD, PhD; Myung, Seung-Jae MD, PhD

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Background: Probiotics confer health benefits to the host. However, its clinical effect on irritable bowel syndrome (IBS) is controversial.

Aims: This study was aimed to evaluate the effects of Saccharomyces boulardii on quality of life (QOL) and symptoms in patients with diarrhea-predominant IBS or mixed-type IBS.

Methods: Sixty-seven patients with IBS were randomized either to receive S. boulardii at 2×1011 live cells as a daily dose (n=34), or placebo (n=33) for 4 weeks. IBS-QOL was assessed at the beginning and end of the treatment phase. IBS-related symptoms, bowel movement frequency, and stool consistency were recorded on a daily basis and assessed each week.

Results: The overall improvement in IBS-QOL was higher in S. boulardii group than placebo (15.4% vs 7.0%; P<0.05). All eight domains of IBS-QOL were significantly improved in S. boulardii group; however, placebo group only showed improvements in dysphoria and health worry. Composite scores for IBS symptoms were significantly reduced in both groups to a similar extent. Bowel frequency and stool consistency did not change in either group.

Conclusions: S. boulardii improved IBS-QOL better than placebo but was not superior for individual symptoms in patients with diarrhea-predominant IBS or mixed-type IBS.

© 2011 Lippincott Williams & Wilkins, Inc.


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