Skip Navigation LinksHome > January 2011 - Volume 45 - Issue 1 > The Role of Duodenal Bulb Biopsy in the Diagnosis of Celiac...
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e3181e04d26
ALIMENTARY TRACT: Original Articles

The Role of Duodenal Bulb Biopsy in the Diagnosis of Celiac Disease in Children

Levinson-Castiel, Rachel MD*; Hartman, Corina MD*; Morgenstern, Sara MD; Avitzur, Yaron MD*,‡; Hirsch, Akiva MD*; Rosenbach, Yoram MD*,‡; Shapiro, Rivka MD*,‡; Zevit, Noam MD*,‡; Fleischaker, Hava RN*; Niv, Yaron MD‡,§; Shamir, Raanan MD*,‡

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Background and Study Aims: It is suggested that for celiac disease (CD) diagnosis, biopsies should also be taken from the duodenal bulb. Whether bulb biopsies suggestive of CD can be found on upper gastrointestinal endoscopy (EGD) done for reasons other than CD diagnosis is not clear. The aim of our study was to evaluate the contribution of routine bulb biopsies to the diagnosis of CD, when taken regardless of prior suspicion of CD.

Methods: The study included 96 children who underwent EGD for suspected CD and a control group of 69 children who underwent EGD for reasons other than CD. The mucosal changes were evaluated using the Marsh-Oberhuber classification.

Results: Among the 87 children diagnosed with CD, we identified 6 patients (7%) with typical histologic findings only in the bulb (Marsh 3), but also 1 patient (1.1%) with findings only in the distal duodenum (Marsh 2). In 20 patients (23%) the histological changes were more severe in the bulb. One patient had more prominent findings in the second part of the duodenum. None of the control patients had histological changes compatible with CD in the bulb or the second part of the duodenum.

Conclusions: Our findings suggest that when CD is suspected, biopsies should be taken from both locations (bulb and second part) as mucosal changes may emerge only at one site. Nevertheless, the presence of characteristic histology on duodenal bulb biopsies might be sufficient for the diagnosis of CD.

© 2011 Lippincott Williams & Wilkins, Inc.


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