Background: Metastatic carcinoid tumors (MCTs), an important subgroup of neuroendocrine tumors, occur infrequently and often have an indolent course, limiting data on long-term treatment outcomes. We aimed to assess treatment trends at a single center over time and the impact on the outcome.
Study: Patients diagnosed with carcinoid tumors in the North West Adelaide Health Service between January 1, 1985 and March 1, 2007 were identified from the South Australian Cancer Registry.
Results: We identified 92 patients with carcinoid tumors; 49 had MCT. Although treatment options increased over time, the most significant change was to access octreotide therapy, with 24 receiving long-acting somatostatin analogs. Survival improved over time and the median overall survival for patients receiving long-acting somatostatin analogs was 112 months compared with 53 months for those who did not (P=0.021, hazard ratio: 2.46). Ten year survival was 40% and 22%, respectively. About 75% of evaluable patients had a biochemical response to initial therapy and a measurable response occurred in 3 of 24 (13%) patients.
Conclusions: This single center experience has provided insight into current treatment options for MCT, and suggests the use of long-acting somatostatin analogs may impact on disease control and survival. However, the uptake of other treatment options seems limited and there is a need for agents that target tumor progression.
*Department of Medical Oncology, The Queen Elizabeth Hospital
†Department of Medical Oncology, The Queen Elizabeth Hospital and University of Adelaide
‡Department of Health, Epidemiology Branch, Adelaide, SA, Australia
Funding: There was no funding for this project.
Reprints: Amanda Townsend, MBBS, FRACP, Department of Medical Oncology, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, SA 5011, Australia (e-mail: Amanda.firstname.lastname@example.org).
Received for publication January 23, 2009
accepted April 10, 2009
Conflict of Interest: There are no conflicts of interest to declare.