Skip Navigation LinksHome > March 2010 - Volume 44 - Issue 3 > Helicobacter pylori-negative Gastritis in Erosive Esophagiti...
Journal of Clinical Gastroenterology:
doi: 10.1097/MCG.0b013e3181ac9830
ALIMENTARY TRACT: Original Articles

Helicobacter pylori-negative Gastritis in Erosive Esophagitis, Nonerosive Reflux Disease or Functional Dyspepsia Patients

Peura, David A. MD*; Haber, Marian M. MD; Hunt, Barbara MS; Atkinson, Stuart MB ChB

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Abstract

Background: Although Helicobacter pylori infection is believed to be the main cause of chronic gastritis, a US clinical trial investigating the long-term effects of lansoprazole as maintenance therapy for erosive esophagitis revealed a surprisingly high prevalence (over 90%) and severity of chronic gastritis in H. pylori-negative subjects.

Goals: This study aims to compare prevalence and severity of chronic gastritis of the body and antrum in H. pylori-negative subjects with erosive esophagitis, nonerosive reflux disease, or functional dyspepsia from several trials.

Study: Pretreatment gastric histology was compared in 1595 H. pylori-negative subjects with erosive esophagitis (≥ grade 2; n=196), nonerosive reflux disease (n=688), or functional dyspepsia (n=711) who participated in US Takeda-sponsored lansoprazole trials.

Results: Pretreatment histology data from US clinical studies showed that 67.5% and 75.0% of H. pylori-negative adult subjects with erosive esophagitis had moderate or severe body and antral chronic gastritis, respectively. Chronic gastritis was also observed in H. pylori-negative subjects with nonerosive reflux disease or functional dyspepsia, although prevalence was significantly less (P<0.001) than in erosive esophagitis.

Conclusions: Chronic gastritis in H. pylori-negative subjects is more common than previously appreciated. These results highlight the need for better characterization of gastric mucosal histology in these gastrointestinal disorders.

© 2010 Lippincott Williams & Wilkins, Inc.

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