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Probiotics in the Treatment of Human Inflammatory Bowel Diseases: Update 2008

Fedorak, Richard Neil MD; Dieleman, Levinus Albert MD, PhD

Journal of Clinical Gastroenterology: July 2008 - Volume 42 - Issue - pp S97-S103
doi: 10.1097/MCG.0b013e3181618ac7
Presentations

Probiotic research and clinical trials have been forging ahead over the last decade. Although much has been learnt in relation to probiotic intestinal epithelial-mucosal immune interactions, the evidence for substantial clinical efficacy of probiotics continues to progress much slower. This review outlines the probiotic clinical studies before 2005 that formed the foundation of probiotic clinical trials in inflammatory bowel disease and then examines indepth those inflammatory bowel disease probiotic clinical trials published after 2005 that are leading to new understanding of the role of probiotics in the induction and remission of inflammatory bowel disease in humans.

Division of Gastroenterology, University of Alberta, Edmonton, Alberta

Richard N Fedorak, MD—Summary of Conflict of Interest Statements 2007.

Advisory Board Member: Abbott Canada, Axcan, Celltech, Elan/Biogen, Proctor & Gamble, Schering Canada, Shire, UCB Pharma, VSL3.

Recipient of Clinical/Basic Research Grants: Abbott, Altana/Nycomed, AstraZeneca, Axcan, Berlex, Bristol Myers Squibb, Centocor, Elan/Biogen, Ferring, Millenium, Novartis, Otsuka, Proctor & Gamble, Protein Design Labs, Schering, Synta, Tillots, UCB Pharma, VSL3.

Participant in Speaker's Bureau: Abbott, Altana/Nycomed, Axcan, Centocor, Ferring, Proctor & Gamble, Schering, Shire, UCB Pharma, VSL3.

Receipt of Consultation Fees: Abbott, Altana/Nycomed, AstraZeneca, Axcan, Berlex, Bristol Myers Squibb, Centocor, Elan/Biogen, Ferring, Millenium, Novartis, Otsuka, Proctor & Gamble, Protein Design Labs, Schering, Synta, Tillots, UCB Pharma, VSL3.

Levinus A. Dieleman, MD, PhD—Summary of Conflict of Interest Statements 2007.

Advisory Board Member: Abbott Canada.

Recipient of Clinical/Basic Research Grants: Abbott, Orafti.

Receipt of Consultation Fees: Abbott, Schering.

Reprints: Dr Richard Neil Fedorak, MD, Division of Gastroenterology, University of Alberta, Zeidler Ledcor Centre, Edmonton, AB T6G 2×8 (e-mail: richard.fedorak@ualberta.ca).

Received for publication November 6, 2007; accepted November 7, 2007

© 2008 Lippincott Williams & Wilkins, Inc.