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Solid-pseudopapillary Tumor of the Pancreas

Seo, Hyang-Eun MD*; Lee, Myung-Kwon MD*; Lee, Young-Doo MD*; Jeon, Seong-Woo MD*; Cho, Chang-Min MD*; Tak, Won-Young MD*; Kweon, Young-Oh MD*; Kim, Sung-Kook MD*; Choi, Yong-Hwan MD*; Bae, Han-Ik MD; Kim, Sang-Geol MD; Yoon, Young-Kook MD

doi: 10.1097/01.mcg.0000225671.91722.10
Liver, Pancreas, and Biliary Tract: Clinical Research

Background: Solid-pseudopapillary tumor (SPT) of the pancreas is a low-grade malignancy, which has been infrequently observed in adolescent and young adult females since first report by Frantz in 1959. In this article, we describe our experience of 8 cases of SPT with the clinical features, diagnosis, treatments, and outcomes.

Methods: We retrospectively reviewed the medical records and images of 8 patients who underwent surgery for SPT between January 1995 and December 2004.

Results: Seven females and 1 male with the mean age of 29 years (range, 10 to 64) at presentation were identified. Three patients presented palpable abdominal mass, 2 with abdominal pain, and the remainder with no specific symptom. The mean diameter of the tumors was 7.9 cm (range, 4.0 to 10.0). Four were located in the tail, 3 in the body, and 1 in the head. Surgical procedure included distal pancreatectomy with/without splenectomy in 7 patients and Whipple operation in 1 with no surgical morbidity and mortality. All were alive without evidence of recurrence after mean follow-up of 26.4 months (range, 1 to 66).

Conclusions: SPT of the pancreas is an unusual neoplasm and typically occurs in young females presenting well-demarcated pancreatic masses, which are amenable to cure by complete surgical resection.

Departments of *Internal Medicine

Pathology

Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea

Reprints: Chang-Min Cho, MD, Division of Gastroenterology, Department of Internal Medicine, Kyungpook National University Hospital, 50, Samduk 2-Ga, Chung-Gu, Daegu 700-721, South Korea (e-mail: cmcho@knu.ac.kr).

Received for publication June 1, 2005; accepted June 27, 2006

© 2006 Lippincott Williams & Wilkins, Inc.