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Hydranencephaly With Cholestasis and Giant Hepatitis

Kawashima, Hisashi MD, PhD*; Watanabe, Chiako MD*; Nishimata, Shigeo MD, PhD*; Kashiwagi, Yasuyo MD, PhD*; Ioi, Hiroaki MD*; Takekuma, Kouji MD, PhD*; Kage, Masayoshi MD, PhD

doi: 10.1097/01.mcg.0000225690.67959.c3
Liver, Pancreas, and Biliary Tract: Case Report

We present a rare case of hydranencephaly with cholestasis and giant hepatitis. Studies for infectious agents were all negative including for the detection of virus in liver tissue by using polymerase chain reaction. Although the anterior pituitary functions (cortisol, thyroid stimulating hormone, free T4, human growth hormone) were normal, the patient revealed massive cholestasis and giant hepatitis.

*Department of Pediatrics, Tokyo Medical University, Tokyo, Japan

The First Department of Pathology, Kurume University, Fukuoka, Japan

Reprints: Hisashi Kawashima, MD, PhD, Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan (e-mail: hisashi@tokyo-med.ac.jp).

Received for publication November 1, 2005; accepted May 11, 2006

© 2006 Lippincott Williams & Wilkins, Inc.