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Co-occurrence of Hepatocellular Carcinoma and Lymphoma in Patients with Hepatitis C Virus Cirrhosis

Shapira, Michael Y. M.D.; Muszkat, Mordechai M.D.; Braunstein, Isabella M.D.; Gotsman, Israel M.D.

Journal of Clinical Gastroenterology:
Brief Case Reports

The association of hepatitis C virus (HCV) with neoplasia is not completely understood. Hepatitis C virus is hepatolymphotrophic. It is considered an inducing factor of hepatocellular carcinoma (HCC) and is associated with various types of lymphomas. We describe a patient with HCV cirrhosis who developed gastric lymphoma and HCC, and we review the current data and theories about the oncogenesis of HCV.

Author Information

From the Division of Medicine, Hadassah University Hospital, Hebrew University–Hadassah Medical School, Jerusalem, Israel.

Address correspondence and reprint requests to Dr. Israel Gotsman, Division of Medicine, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel 91120. E-mail:

© 2001 Lippincott Williams & Wilkins, Inc.