Skip Navigation LinksHome > June 1997 - Volume 24 - Issue 4 > Severe Hepatotoxicity on Beginning Propylthiouracil Therapy
Journal of Clinical Gastroenterology:
Case Studies

Severe Hepatotoxicity on Beginning Propylthiouracil Therapy

Lock, Dennis R. M.D.; Sthoeger, Zev M. M.D.

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Abstract

We report a case of propylthiouracil (PTU)-induced cholestatic hepatotoxicity in Graves' disease that developed 1 day after beginning PTU. After clinical recovery, liver abnormalities persisted for 5 years. Percutaneous liver biopsy and the eventual normalization of enzyme levels excluded permanent liver damage as a result of PTU therapy. Thus prolonged elevation of serum enzymes is consistent with the diagnosis of PTU-induced hepatotoxicity, which may recover completely.

© Lippincott-Raven Publishers

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