Skip Navigation LinksHome > June 1997 - Volume 24 - Issue 4 > Pyrazinamide-Induced Granulomatous Hepatitis
Journal of Clinical Gastroenterology:
Case Studies

Pyrazinamide-Induced Granulomatous Hepatitis

Knobel, Boleslaw M.D.; Buyanowsky, George M.D.; Dan, Michael M.D.; Zaidel, Liliana M.D.

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Noncaseating granulomatous hepatitis may be caused by a variety of drugs, but we have not found, by computer search of the literature, a previous describe of granulomatous hepatitis associated with pyrazinamide. We describe a 52-year-old man with hectic fever, chills, extreme fatigue, liver damage, and hyperuricemia about 4 weeks after commencing pyrazinamide therapy. A liver biopsy specimen showed noncaseating epithelioid granulomas. The patient recovered soon after the interruption of tuberculostatic treatment.

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