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Shortened Mean Transit Time in CT Perfusion With Singular Value Decomposition Analysis in Acute Cerebral Infarction: Quantitative Evaluation and Comparison With Various CT Perfusion Parameters

Murayama, Kazuhiro MD, PhD; Katada, Kazuhiro MD, PhD; Hayakawa, Motoharu MD, PhD; Toyama, Hiroshi MD, PhD

Journal of Computer Assisted Tomography: March/April 2017 - Volume 41 - Issue 2 - p 173–180
doi: 10.1097/RCT.0000000000000498
Neuroradiology

Objective We aimed to clarify the cause of shortened mean transit time (MTT) in acute ischemic cerebrovascular disease and examined its relationship with reperfusion.

Methods Twenty-three patients with acute ischemic cerebrovascular disease underwent whole-brain computed tomography perfusion (CTP). The maximum MTT (MTTmax), minimum MTT (MTTmin), ratio of maximum and minimum MTT (MTTmin/max), and minimum cerebral blood volume (CBV) (CBVmin) were measured by automatic region of interest analysis. Diffusion weighted image was performed to calculate infarction volume. We compared these CTP parameters between reperfusion and nonreperfusion groups and calculated correlation coefficients between the infarction core volume and CTP parameters.

Results Significant differences were observed between reperfusion and nonreperfusion groups (MTTmin/max: P = 0.014; CBVmin ratio: P = 0.038). Regression analysis of CTP and high-intensity volume on diffusion weighted image showed negative correlation (CBVmin ratio: r = −0.41; MTTmin/max: r = −0.30; MTTmin ratio: r = −0.27).

Conclusions A region of shortened MTT indicated obstructed blood flow, which was attributed to the singular value decomposition method error.

From the *Department of Radiology, Fujita Health University; †Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University; and ‡Department of Neurosurgery, Fujita Health University, Toyoake, Japan.

Received for publication April 5, 2016; accepted June 1, 2016.

Correspondence to: Kazuhiro Murayama, MD, PhD, Department of Radiology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho Toyoake, Aichi, 470-1101, Japan (e-mail: kmura@fujita-hu.ac.jp).

Supported by Toshiba Medical Systems Corporation.

This work was presented at the 41st Annual Meeting of the Japanese Society of Neuroradiology in Mie, 2012. Shortened Mean Transit Time in CT Perfusion with Singular Value Decomposition Analysis in Acute Cerebral Infarction: Quantitative Evaluation and Comparison with Various CT Perfusion Parameters.

The authors declare no conflict of interest.

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