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Imaging Features of Growing Teratoma Syndrome Following a Malignant Ovarian Germ Cell Tumor

Han, Na Yeon MD, PhD*; Sung, Deuk Jae MD, PhD*; Park, Beom Jin MD, PhD*; Kim, Min Ju MD, PhD*; Cho, Sung Bum MD, PhD*; Kim, Kyeong Ah MD, PhD; Song, Jae Yun MD, PhD

Journal of Computer Assisted Tomography: July/August 2014 - Volume 38 - Issue 4 - p 551–557
doi: 10.1097/RCT.0000000000000073
Abdominal Imaging

Objective: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy.

Methods: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition.

Results: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient.

Conclusions: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.

From the *Department of Radiology, College of Medicine, Korea University, Anam Hospital, Seoul, Republic of Korea; †Department of Radiology, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea; and ‡Department of Obstetrics and Gynecology, College of Medicine, Korea University, Anam Hospital, Seoul, Republic of Korea.

Received for publication November 26, 2013; accepted January 8, 2014.

Reprints: Deuk Jae Sung, MD, PhD, Department of Radiology, College of Medicine, Korea University, Anam Hospital, 126–1 5-Ka, Anam-Dong, Sungbuk-ku, Seoul 136–705, Republic of Korea (e-mail:

The authors declare no conflict of interest.

© 2014 by Lippincott Williams & Wilkins