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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0000000000000067
Thoracic Imaging

Can Full-Dose Contrast-Enhanced CT Be Omitted From an FDG-PET/CT Staging Examination in Newly Diagnosed FDG-Avid Lymphoma?

van Hamersvelt, Hanneke P. MD*; Kwee, Thomas C. MD, PhD*; Fijnheer, Rob MD, PhD; Beek, Frederik J.A. MD, PhD*; de Klerk, John M.H. MD, PhD; Nievelstein, Rutger A.J. MD, PhD*

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Abstract

Objective

To determine whether full-dose contrast-enhanced computed tomography (CT) (CECT) can be omitted from an 18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) (FDG-PET)/CT staging examination in newly diagnosed FDG-avid lymphoma.

Methods

Twenty-nine patients with newly diagnosed FDG-avid lymphoma prospectively underwent unenhanced low-dose FDG-PET/CT and CECT. Different observers evaluated unenhanced low-dose FDG-PET/CT and CECT in a blinded manner. Ann Arbor stages according to unenhanced low-dose FDG-PET/CT and CECT were compared, and discrepancies between the 2 imaging modalities were resolved using bone marrow biopsy and posttreatment FDG-PET/CT as reference standard. Finally, it was assessed as to how many cases therapy would have been changed based on additional CECT findings.

Results

In 27 of 29 patients (93%; 95% confidence interval, 78%–98%), CECT either did not change or did not correctly change the Ann Arbor stage that was assigned according to unenhanced low-dose FDG-PET findings. In 2 of 29 patients (7%; 95% confidence interval, 2%–22%), CECT correctly provided another Ann Arbor stage than unenhanced low-dose FDG-PET/CT. In the latter 2 cases, therapy would not have been changed based on additional CECT findings.

Conclusions

Unenhanced low-dose FDG-PET/CT alone is suggested as the primary imaging modality of choice for staging patients with newly diagnosed FDG-avid lymphoma. This diagnostic approach is particularly indicated in younger patients in whom diagnostic radiation exposure should be minimized and in patients who are at increased risk of CT contrast-induced allergic reactions or nephropathy.

Copyright © 2014 by Lippincott Williams & Wilkins

  

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