Skip Navigation LinksHome > March/April 2014 - Volume 38 - Issue 2 > Clear Cell Meningioma: Clinical Features, CT, and MR Imaging...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0000000000000018
Neuroradiology

Clear Cell Meningioma: Clinical Features, CT, and MR Imaging Findings in 23 Patients

Wang, Xiao-Qiang PhD*; Huang, Ming-Zhu MD, PhD; Zhang, Hua MD, PhD; Sun, Feng-Bing MD*; Tao, Bang-Bao MD*; Feng, Bao-Hui MD*; Liao, Chen-Long MD*; Kochanski, Ryan PhD§; Hua, Xu-Ming PhD*; Li, Shi-Ting MD, PhD*

Collapse Box

Abstract

Background

Clear cell meningioma (CCM) is a rare meningioma, with radiologic features not well characterized in literature. The purpose of this study was to describe and characterize the clinical features and imaging findings of CCM.

Materials and Methods

The computed tomography (n = 16) and magnetic resonance (n = 23) images of 23 patients (12 men and 11 women; mean age, 34.6 years) were retrospectively reviewed. All of the patients underwent surgical resection. Follow-up was performed through clinical observations.

Results

Cerebellopontine angle was the most frequently presenting location (n = 10). The tumors were isointense (n = 12) or hypointense but associated with isointense (n = 7) appearance to gray matter on T1-weighted images. However, the tumors seemed to be isointense (n = 6) or isointense and hyperintense (n = 13) on T2-weighted images. On gadolinium-enhanced T1-weighted images, heterogeneous enhancement was seen in 14 lesions. Four lesions had amorphous calcifications, 18 showed peritumoral edema, 14 had cystic areas, 2 had bone hyperostosis, and 8 manifested bone destruction. On initial surgery, 17 patients underwent complete resection, whereas 5 patients underwent subtotal resection of their tumors. The operative result for the remaining patient was unknown. Follow-up was possible in 22 patients. Eleven patients had recurrence and 2 had died.

Conclusions

Clear cell meningioma is a rare subtype of meningioma that occurs in younger patients and often recurs. Cerebellopontine angle is the most affected area in this series. The extent of initial surgical resection is the most important prognostic factor. In radiological studies, CCM tends to have marked heterogeneous enhancement, prominent peritumoral edema, intratumoral cystic components, and involvement of the adjacent bone.

Copyright © 2014 by Lippincott Williams & Wilkins

  

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.