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In Vivo and Ex Vivo Magnetic Resonance Spectroscopy in the Characterization of Hemangioblastoma Cyst Fluid

Crisi, Girolamo MD*; Filice, Silvano MSc; Pertinhez, Thelma A. PhD; Ventura, Elisa MD§; Servadei, Franco MD

Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182a9103a

Abstract: Peritumoral cyst formation is commonly associated with hemangioblastomas of the central nervous system. Results of a proteomic profiling of hemangioblastoma cyst fluid suggested that cyst formation, whether intratumoral or peritumoral, is a consequence of vascular leakage because protein profiles of cyst fluid and blood serum were similar. To the best of our knowledge, this is the first report of in vivo and ex vivo magnetic resonance spectroscopy analyses of hemangioblastoma cyst fluid that investigates on the mechanism leading to peritumoral cyst formation.

Author Information

From the Departments of *Neuroscience, Section of Neuroradiology, and †Medical Physics, University Hospital of Parma, ‡Measurement Interdepartmental Centre Laboratory, Technopole Parma, University of Parma, Departments of §Neuroscience, Section of Neuroradiology, and ║Emergency-Urgency, Section of Neurosurgery, University Hospital of Parma, Parma, Italy.

Received for publication August 9, 2013; accepted August 12, 2013.

Reprints: Girolamo Crisi, MD, Department of Neuroscience, Section of Neuroradiology, University Hospital of Parma, via Gramsci 14, 43126, Parma, Italy (e-mail:

The authors declare no conflict of interest.

© 2014 by Lippincott Williams & Wilkins