Skip Navigation LinksHome > January/February 2014 - Volume 38 - Issue 1 > Identifying the Central Sulcus in Patients With Intra-axial...
Text sizing:
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182a589e0

Identifying the Central Sulcus in Patients With Intra-axial Lesions: A Multicenter Study Comparing Conventional Presurgical MRI to Topographical Analysis and BOLD-fMRI

Due-Tonnessen, Paulina MD*†; Rasmussen, Inge MD, PhD†‡; Berntsen, Erik Magnus MD, PhD§; Bjornerud, Atle PhD†∥; Emblem, Kyrre E. PhD

Collapse Box


Objectives: Identification of eloquent brain areas in patients with intra-axial lesions is important to minimize the risk of neurological deficit. We performed a multicenter study comparing conventional 2-dimensional magnetic resonance imaging (MRI) for identification of the central sulcus to topographical MRI and blood-oxygenation-level-dependent functional MRI (BOLD-fMRI).

Methods: Seventy-seven unoperated patients with brain lesions were imaged at 1.5 or 3 T. The central sulcus was identified by an experienced neuroradiologist on 2-dimensional MRI, by topographic analysis of 3-dimensional MRI in BrainVoyager, and by BOLD-fMRI analysis in BrainVoyager or SPM5.

Results: The central sulcus in the affected hemisphere was readily identified in a significantly higher percentage of patients by 2-dimensional MRI and topographical analysis (77/77 patients) compared to BOLD-fMRI (57 patients; P < 0.001). The topographical analysis identified a significantly larger portion of the total central sulcus than 2-dimensional MRI (P < 0.05). No differences were found between institutions, histological versus radiological diagnoses, MRI sequence parameters, age, or sex.

Conclusions: Identification of the central sulcus is best performed using topographical analysis; however, 2-dimensional analysis may suffice for daily routine work.

© 2014 by Lippincott Williams & Wilkins



Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.