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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182a91006
Abdominal Imaging

Focal Nodular Hyperplasia of the Liver: Diffusion-Weighted Magnetic Resonance Imaging Characteristics Using High b Values

Dohan, Anthony MD*†‡; Soyer, Philippe MD, PhD*†‡; Guerrache, Youcef MD*; Hoeffel, Christine MD, PhD§; Gavini, Jean-Philippe MD*; Kaci, Rachid MD; Boudiaf, Mourad MD*

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Abstract

Objective

To qualitatively and quantitatively assess the presentation of hepatic focal nodular hyperplasia (FNH) at diffusion-weighted magnetic resonance imaging (DWMRI) using multiple high b values.

Materials and Methods

Twenty-five patients with 27 FNHs had liver DWMRI at 1.5 T using free-breathing acquisition and 3 b values (0, 600, 1000 s/mm2). Focal nodular hyperplasias were evaluated qualitatively using visual analysis of diffusion-weighted magnetic resonance (DWMR) images and quantitatively using conventional apparent diffusion coefficient (ADC) and normalized ADC measurements.

Results

All FNHs (100%) were visible on b0 DWMR images; 26 of the 27 FNHs (96%), on b600 DWMR images; and 21 of the 27 FNHs (78%), on b1000 DWMR images. A total of 18 of the 27 FNHs (67%) exhibited a hyperintense central scar on the b0 DWMR images that remained visible on the b600 and b1000 DWMR images in 6 of the 27 FNHs (22%). Conventional ADC value of FNHs (1.318 × 10−3 mm2/±0.208) was significantly lower than that of adjacent hepatic parenchyma (1.414 × 10−3 mm2/s ± 1.95) (P = 0.0003), although a substantial overlap was found. The use of normalized ADC using the liver as reference organ resulted in a more restricted distribution of ADC values (variation coefficient, 5.3%).

Conclusions

Focal nodular hyperplasias show a wide range of morphological features at DWMRI using high b values. Further studies are needed to fully investigate as to what extent normalized ADC may result in better lesion characterization.

Copyright © 2014 by Lippincott Williams & Wilkins

  

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