Skip Navigation LinksHome > January/February 2014 - Volume 38 - Issue 1 > Evaluation of Hepatic Fibrosis Using Intravoxel Incoherent M...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182a589be
Abdominal Imaging

Evaluation of Hepatic Fibrosis Using Intravoxel Incoherent Motion in Diffusion-Weighted Liver MRI

Yoon, Jeong Hee MD*; Lee, Jeong Min MD*†; Baek, Jee Hyun MD*†; Shin, Cheong-il MD*; Kiefer, Berthold PhD; Han, Joon Koo MD*†; Choi, Byung-Ihn MD*†

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Abstract

Objectives

To determine whether intravoxel incoherent motion (IVIM)–diffusion-weighted image (DWI)–derived parameters showed better diagnostic performance than the apparent diffusion coefficient (ADCtotal) for the evaluation of hepatic fibrosis (HF).

Methods

This retrospective study was approved by institutional review board, and informed consent was waived. Fifty-five patients with chronic liver disease who had undergone IVIM-DWI using 8 b-values at 3 T were included. True diffusion coefficient (Dt), pseudo-diffusion coefficient (Dp), perfusion fraction (f), and ADCtotal were calculated. Receiver operating characteristic analysis was performed for all parameters for the HF staging.

Results

All parameters showed a significant correlation with the HF stages (−0.31 to −0.72, P < 0.05). All parameters were significantly higher in F0 to F1 than in F4 (P < 0.05). The Dp showed better performance than the ADCtotal in differentiating significant HF (≥F2) from F0 to F1.

Conclusions

The IVIM-derived parameters and ADCtotal showed significant correlation with HF. The Dp showed better diagnostic performance for differentiating significant HF than did ADCtotal.

Copyright © 2014 by Lippincott Williams & Wilkins

  

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