Skip Navigation LinksHome > January/February 2014 - Volume 38 - Issue 1 > Dual-Energy CT Perfusion During Pharmacologic Stress for the...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182a77626
Cardiovascular Imaging

Dual-Energy CT Perfusion During Pharmacologic Stress for the Assessment of Myocardial Perfusion Defects Using a Second-Generation Dual-Source CT: A Comparison With Cardiac Magnetic Resonance Imaging

Kim, Sung Mok MD*†; Chang, Sung-A MD†‡; Shin, Wonseon MD; Choe, Yeon Hyeon MD, PhD*†

Collapse Box

Abstract

Objectives

This study aimed to assess the diagnostic performance of adenosine-stress dual-energy myocardial computed tomography perfusion (DECTP) imaging using 128-slice dual-source computed tomography (CT) for the detection of myocardial perfusion defects in comparison with stress-perfusion magnetic resonance imaging (MRI).

Methods

This prospective study included 50 patients (mean age, 66 [9] years; 64% men) with suspected coronary artery disease who underwent adenosine-stress DECTP using 128-slice dual-source CT as well as adenosine-stress cardiac MRI using a 1.5-T scanner. Estimates of diagnostic accuracy in detecting myocardial perfusion defects were calculatedand compared with those of cardiac MRI.

Results

The estimates of diagnostic accuracy in detecting myocardial perfusion defects using DECTP were as follows: sensitivity, 77% (95% confidence interval [CI], 67%–87%); specificity, 94% (95% CI, 92%–95%); positive predictive value, 53% (95% CI, 44%–63%); and negative predictive value, 98% (95% CI, 97%–99%). The results of DECTP imaging were positively correlated with those of cardiac MRI (r = 0.602, P < 0.001). Mean effective radiation doses for stress DECTP imaging and rest coronary CTA were 6.5 (2.2) and 4.9 (1.7) mSv, respectively.

Conclusions

Adenosine-stress DECTP imaging enables detection of myocardial ischemia. However, further technical developments are necessary to reduce artifacts and improve the sensitivity of DECTP.

Copyright © 2014 by Lippincott Williams & Wilkins

 

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.