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Correlations Between Tumor Stroma Characters and Dynamic Enhanced MDCT Findings in Nodular Pulmonary Adenocarcinoma

Wang, Yong MD*; Wang, Jin-an MD*; Liang, Kun-ru MD*; Liang, Ming-zhu MD; Liu, Xue-guo MD, PhD

Journal of Computer Assisted Tomography: January/February 2014 - Volume 38 - Issue 1 - p 82–88
doi: 10.1097/RCT.0b013e3182a38ad5
Thoracic Imaging

Objective: This study aimed to evaluate correlations between tumor stroma characters and dynamic contrast-enhanced computed tomographic (CT) findings in nodular pulmonary adenocarcinoma.

Methods: Thirty-three patients with nodular pulmonary adenocarcinoma underwent dynamic contrast-enhancement CT scan before surgery. CT findings include wash-in, wash-out, and distribution of enhancement. The proportion of invasive and noninvasive stroma in tumor was calculated.

Results: Invasive and noninvasive stroma proportion in tumor was correlated positively with wash-in and wash-out enhancement, respectively.

Conclusions: Tumor stroma proliferation may explain the pathologic basis of CT dynamic enhancement and be a useful prognostic factor of pulmonary adenocarcinoma.

From the *Department of Radiology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian Province; and †Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guang Dong Province, China.

Received for publication May 9, 2013; accepted July 2, 2013.

Reprints: Xue-guo Liu, MD, PhD, Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, 52 Mei Hua East Rd, Zhuhai 519000, Guang Dong Province, China (e-mail:

The authors have no conflicts of interest to report.

© 2014 by Lippincott Williams & Wilkins