Objective: This study aimed to evaluate correlations between tumor stroma characters and dynamic contrast-enhanced computed tomographic (CT) findings in nodular pulmonary adenocarcinoma.
Methods: Thirty-three patients with nodular pulmonary adenocarcinoma underwent dynamic contrast-enhancement CT scan before surgery. CT findings include wash-in, wash-out, and distribution of enhancement. The proportion of invasive and noninvasive stroma in tumor was calculated.
Results: Invasive and noninvasive stroma proportion in tumor was correlated positively with wash-in and wash-out enhancement, respectively.
Conclusions: Tumor stroma proliferation may explain the pathologic basis of CT dynamic enhancement and be a useful prognostic factor of pulmonary adenocarcinoma.
From the *Department of Radiology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian Province; and †Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guang Dong Province, China.
Received for publication May 9, 2013; accepted July 2, 2013.
Reprints: Xue-guo Liu, MD, PhD, Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, 52 Mei Hua East Rd, Zhuhai 519000, Guang Dong Province, China (e-mail: firstname.lastname@example.org).
The authors have no conflicts of interest to report.