Objective: To study the impact of sinogram-affirmed iterative reconstruction (SAFIRE) and concurrent application of automated tube voltage selection (ATVS) on image quality (IQ) and radiation dose.
Methods: A phantom was scanned using various computed tomography (CT) parameters (kV, 80–120; mAs, 50–200). Abdomen contrast-enhanced CT (CECTs) in 170 adults were performed using dose-modified protocols: in 145 patients (group I), ATVS was applied (mAs, 111–649); in 25 (group II), the kV was fixed at 120 (reference mAs, 150). In 95 patients, standard-dose (SD) scan was available. Two readers evaluated the IQ of filtered back projection (FBP) and SAFIRE (levels 1, 3, and 5) images.
Results: In phantom, nonlinear drop in noise with increasing strengths of IR (levels S1–S5) was noted. The dose-modified IR scan was rated diagnostic in all 170 patients, with IQ score comparable to that of SD-FBP (P = 0.3). Lower kV (100/80) was prescribed by ATVS in 70% examinations in group I. In comparison with SD-FBP, the mean dose in CT dose index in group I (IR, 3.2 mGy; SD-FBP, 13.02 mGy; P < 0.0001) and in group II (IR, 4.8 mGy; SD-FBP, 11.8 mGy; P < 0.001) was 75.4% and 59.3% lower.
Conclusions: Use of SAFIRE and ATVS provides diagnostic quality images at 59.3% to 75.4% reduced dose compared with SD-FBP scan.