Skip Navigation LinksHome > July/August 2013 - Volume 37 - Issue 4 > Utility of Diffusion-Weighted Imaging in Differentiating Mal...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31828d28f0
Neuroradiology

Utility of Diffusion-Weighted Imaging in Differentiating Malignant From Benign Thyroid Nodules With Magnetic Resonance Imaging and Pathologic Correlation

Shi, Hai Feng MD*; Feng, Qin MD; Qiang, Jin Wei MD, PhD*; Li, Ruo Kun MD, PhD*; Wang, Li MD; Yu, Jian Ping MD§

Collapse Box

Abstract

Objective

The objective of this study was to evaluate the role of magnetic resonance diffusion-weighted imaging (DWI) in differentiating malignant from benign thyroid nodules.

Methods

The prospective study included 111 consecutive patients with solitary thyroid nodules (23 malignant and 88 benign nodules) who underwent DWI. The DWI signal and apparent diffusion coefficient (ADC) values of the nodules were determined and correlated with the histopathologic findings.

Results

The majority (65%) of malignant thyroid nodules showed slightly hyperintense, and the majority (69%) of benign nodules were hyperintense on DWI (P < 0.01). The ADC values were lower in the thyroid cancer than in the adenoma and nodular goiter (P < 0.05). When the b factor was 500 s/mm2, an ADC value of 1.704 × 10−3 mm2/s can be threshold differentiating malignant from benign nodules, with 92% sensitivity, 88% specificity, and 87% accuracy. The higher cell density and more severe desmoplastic response were the causes of the lower ADC value of thyroid cancer.

Conclusion

Diffusion-weighted imaging can be a promising noninvasive imaging to discriminate malignant from benign nodules.

Copyright © 2013 by Lippincott Williams & Wilkins

  

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.