Objective: The objective of this study was to evaluate computed tomography (CT) findings in patients with sepsis with unknown inflammatory focus and acute respiratory distress syndrome.
Methods: Acute respiratory distress syndrome findings on CT of 36 patients with sepsis were graded on a 6-point scale, and the percentage of affected lung was estimated. Resulting CT scores were correlated to intensive care scores and survival.
Results: Forty-four percent of the patients died, revealing a significantly higher CT score than survivors (P = 0.01). Survivors showed larger areas of unaffected lung (P < 0.001), whereas patients with fatal outcome had more ground-glass opacities (P = 0.002; sensitivity, 73%; specificity, 57%) and traction bronchiectasis (P = 0.009; sensitivity, 54%; specificity, 68%). Pulmonary findings on CT did not allow discriminating between a pulmonary and extrapulmonary focus. No significant coherence between CT score and intensive care scores could be revealed.
Conclusions: A CT scoring system based on pulmonary findings in patients with sepsis with acute respiratory distress syndrome comprises prognostic implications in terms of the patients’ survival.
From the *Klinik für Radiologie, Charité–Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin; †Klinik für Anaesthesiologie, Klinikum der Universität München, Ludwig-Maximilian-Universität München, München; and ‡Klinik für Anästhesiologie mit Schwerpunkt Operative Intensivmedizin, Charité–Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
Received for publication February 5, 2013; accepted April 2, 2013.
Reprints: Lars Stelter, MD, Klinik für Radiologie, Charité–Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany (e-mail: firstname.lastname@example.org).
Drs Stelter and Steffen contributed equally to this work.
All authors disclose no potential conflict of interest.