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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31829610e5

3-T Magnetic Resonance Angiography in Primary Angiitis of the Central Nervous System

Cosottini, Mirco MD*†; Canovetti, Silvia MD; Pesaresi, Ilaria MD; Desideri, Ilaria MD; Pizzanelli, Chiara MD*; Catarsi, Eleonora MD§; Puglioli, Michele MD; Tavoni, Antonio MD§; Bonuccelli, Ubaldo MD*; Bartolozzi, Carlo MD

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Objective: Primary angiitis of the central nervous system (PACNS) is a rare disease characterized by an inflammatory process of intracranial vessels. Magnetic resonance angiography (MRA) (3 T) offers increased signal-to-noise ratio and background suppression, leading to better depiction of the intracranial vessels. The aim of our work was to compare the sensitivity of 3-T MRA to that of 1.5-T MRA in the diagnosis of PACNS.

Methods: Eight patients with PACNS and signs of angiitis at digital subtraction angiography (DSA) underwent MRA at 1.5 and 3 T. Magnetic resonance angiograms obtained with time-of-flight (TOF) technique were evaluated for the presence of stenosis with respect to DSA.

Results: In PACNS patients, DSA identified 827 intracranial stenoses. Sensitivity for vessel stenosis of 3-T TOF MRA was 47% and 14% for 1.5-T TOF.

Conclusions: Time-of-flight MRA at 3 T improved the sensitivity of MRA in the noninvasive preliminary evaluation of patients with PACNS.

© 2013 by Lippincott Williams & Wilkins



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