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Efficacy and Safety of Computer-Assisted Stereotactic Transplantation of Human Retinal Pigment Epithelium Cells in the Treatment of Parkinson Disease

Xue, Yanzhong BS; Li, Xiuxiu MD; Pang, Shouliang BS; Wang, Yuguo BS; Yao, Jinguo BS; Zhou, Jianfeng BS; Hao, Peilai BS

Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318287367f

Objective: This study explores the efficacy and safety of computer-assisted stereotactic transplantation of human retinal pigment epithelium (hRPE) cells in the treatment of Parkinson disease (PD).

Methods: Guided by computed tomography and magnetic resonance imaging image mergence, we transplanted 4 × 106 hRPE cells into the putamina and lateral ventricles of 17 PD cases by stereotactic surgery. The transplantation site was located in the contralateral side of the symptoms and signs.

Results: At 3 months after operation, the effective rates of cell transplantation were 82.4% in the contralateral site and 64.7% in the ipsilateral site. Minority of the cases had mild dizziness and hemiparesis, but the durations were short.

Conclusions: Computer-assisted stereotactic transplantation of hRPE for the treatment of PD is safe and efficient.

Author Information

From the Department of Neurology, Yishui Central Hospital, Shandong, China.

Received for publication November 3, 2012; accepted January 10, 2013.

Reprints: Yanzhong Xue, Department of Neurology, YiShui Central Hospital, Yishui 276400, Shandong, China (e-mail:

The authors have no conflicts of interest to report.

© 2013 by Lippincott Williams & Wilkins