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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318282d7e2
Neuroradiology

Comparative Evaluation of 3-Dimensional Pseudocontinuous Arterial Spin Labeling With Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Human Glioma

Roy, Bhaswati PhD*; Awasthi, Rishi PhD; Bindal, Amit MCh; Sahoo, Prativa MSc§; Kumar, Rajan MS; Behari, Sanjay MCh; Ojha, Bal K. MCh; Husain, Nuzhat MD; Pandey, Chandra M. PhD#; Rathore, Ram K.S. PhD§; Gupta, Rakesh Kumar MD*

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Abstract

Introduction

The study was performed to compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with 3-dimensional (3D) pseudocontinuous arterial spin labeling (PCASL) MRI in gliomas with an aim to see whether arterial spin labeling (ASL)–derived cerebral blood flow (CBF) values can be used as an alternative to DCE-MRI for its grading.

Materials and Methods

Sixty-four patients with glioma (37 male; mean age, 43 years; 38 high grade and 26 low grade) underwent 3D-PCASL and DCE-MRI. The DCE indices (relative cerebral blood volume, rCBV; relative CBF, rCBF; permeability, ktrans and kep; and leakage, ve) and ASL (absolute and rCBF) values were quantified from the tumors. Student independent t test was used to compare ASL and DCE-MRI indices. Pearson correlation was used to see correlation between DCE- and ASL-derived CBF values in tumor and normal parenchyma.

Results

On Student t test, neither ASL-derived absolute CBF (P = 0.78) nor rCBF (P = 0.12) values were found to be significantly different in 2 groups, whereas DCE indices except ve were significantly higher in high-grade gliomas. Arterial spin labeling–derived rCBF values weakly correlated with DCE-derived rCBF values, whereas these did not show correlation in normal grey (P = 0.12, r = 0.2) and white (P = 0.26, r = 0.14) matter regions.

Conclusions

Three-dimensional pseudocontinuous arterial spin labeling does not appear to be a reliable technique in the current form and may not be a suitable replacement for DCE in grading of glioma.

Copyright © 2013 by Lippincott Williams & Wilkins

 

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