Objective: To investigate the clinicoradiological manifestations of craniofacial bone infarcts in patients with sickle cell disease (SCD).
Materials and Methods: After institutional review board approval, we identified 85 SCD patients who underwent head and neck magnetic resonance imaging (MRI) during a period of 5 years (January 1, 2004–December 31, 2008) and reviewed their clinical presentations and radiological findings.
Results: Of 40 subjects with headache or facial pain, 6 (5 males, 1 female; age range, 2-22 years; 5 Hb SS, 1 Hb SC) were diagnosed with acute bone infarct by MRI. Of these 6, 4 demonstrated infarcts in the mandible. Magnetic resonance images showed bone marrow edema, subperiosteal fluid collections with susceptibility effects suggesting associated hemorrhage, and heterogeneous enhancement.
Conclusions: Acute craniofacial bone infarcts were found in 7% of SCD patients who underwent MRI and in 15% of SCD patients who presented with pain. The MRI showed characteristic imaging findings including marrow edema, subperiosteal hematoma, and heterogeneous enhancement.
From the *Departments of Radiology, and †Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA.
Received for publication June 11, 2012; accepted September 19, 2012.
Reprints: Memi Watanabe, MD, 3rd Floor FGH Bldg, 820 Harrison Ave, Boston, MA 02118 (e-mail: firstname.lastname@example.org).
The authors report no conflicts of interest.