Skip Navigation LinksHome > January/February 2013 - Volume 37 - Issue 1 > Contrast Dose, Temporal Footprint, and Spatial Resolution Tr...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318276fc92

Contrast Dose, Temporal Footprint, and Spatial Resolution Tradeoffs in Dynamic Contrast-Enhanced MRA Performed in a Porcine Model of a Carotid Aneurysm

Ai, Tao MD*; Goerner, Frank PhD; Patel, Nirav MD; Trelles, Miguel MD; Wu, Gang MD*; Li, Xiaoming MD, PhD*; Runge, Val M. MD

Collapse Box


Objective: To evaluate the tradeoffs between temporal and spatial resolution and contrast dosing in dynamic contrast-enhanced magnetic resonance angiography (CE-MRA).

Methods: Bilateral carotid artery aneurysms were created in a swine model. Dynamic CE-MRA using 1 mol/L gadobutrol was performed at 3 T, with high temporal (high-temp), middle temporal (mid-temp), and low temporal (low-temp) resolutions. High temporal CE-MRA was performed twice using 1 mL and 2 mL gadobutrol (2 mL/s). Middle temporal and low-temp sequences were performed once with 2 mL gadobutrol (2 mL/s). The signal-to-noise ratio (SNR) was quantitatively assessed. Blinded reads were used to qualitatively evaluate contrast dose and image quality.

Results: The mean SNRs of high-temp, mid-temp, and low-temp resolutions were 56.7, 47.5, and 48.1. There was no significant difference between the 3 sequences with 2 mL gadobutrol. The mean SNR of the high-temp resolution with 2 mL was significantly higher than that with 1 mL (56.7 vs 39.9). In qualitative analysis, the 3 temporal sequences with 2 mL gadobutrol showed no significant differences regarding overall image quality and diagnostic value. High temporal resolution with 2 mL consistently showed the superiority of image quality than that with 1 mL.

Conclusions: High temporal dynamic CE-MRA with 2 mL (0.04 mmol/kg body weight) gadobutrol can produce consistently superior image quality over that with 1 mL (0.02 mmol/kg body weight). For a given contrast dose, the tradeoffs between temporal and spatial resolution will not result in significant differences in image quality in TWIST (time-resolved angiography with interleaved stochastic trajectories).

© 2013 Lippincott Williams & Wilkins, Inc.



Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.