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Computed Tomography and Magnetic Resonance Imaging of Adult Renal Cell Carcinoma Associated With Xp11.2 Translocation

Dang, Trien T. MD*; Ziv, Etay MD, PhD*; Weinstein, Stefanie MD*; Meng, Maxwell V. MD; Wang, Zhen MD*; Coakley, Fergus V. MD*†

Journal of Computer Assisted Tomography: November/December 2012 - Volume 36 - Issue 6 - p 669–674
doi: 10.1097/RCT.0b013e3182680182
Cardiothoracic Imaging

Objective: This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of renal cell carcinoma associated with Xp11.2 translocation in adults.

Methods: We retrospectively identified 9 adults with renal cell carcinoma associated with Xp11.2 translocation who underwent baseline cross-sectional imaging with CT (n = 9) or MRI (n = 3). All available clinical, imaging, and histopathological records were reviewed.

Results: Mean patient age was 24 years (range, 18–45 years). Eight of 9 cancers demonstrated imaging findings of hemorrhage or necrosis (n = 3), advanced stage disease (n = 2), or both (n = 3) at CT or MRI.

Conclusions: The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.

From the Departments of *Radiology and Biomedical Imaging and †Urology, University of California San Francisco, San Francisco, CA.

Received for publication April 13, 2012; accepted July 3, 2012.

Reprints: Fergus Coakley, MD, Department of Radiology Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L340 Portland, OR 97239 (e-mail:

Dr Ziv was supported by T32 training grant 1 T32 EB001631 from the National Institute of Biomedical Imaging and Bioengineering.

The authors have no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.