Objective: This study aimed to report the computed tomography (CT) and magnetic resonance imaging (MRI) findings of renal cell carcinoma associated with Xp11.2 translocation in adults.
Methods: We retrospectively identified 9 adults with renal cell carcinoma associated with Xp11.2 translocation who underwent baseline cross-sectional imaging with CT (n = 9) or MRI (n = 3). All available clinical, imaging, and histopathological records were reviewed.
Results: Mean patient age was 24 years (range, 18–45 years). Eight of 9 cancers demonstrated imaging findings of hemorrhage or necrosis (n = 3), advanced stage disease (n = 2), or both (n = 3) at CT or MRI.
Conclusions: The possibility of renal cell carcinoma associated with Xp11.2 translocation should be considered for a renal mass seen in a patient 45 years or younger, which demonstrates hemorrhage or necrosis or advanced stage disease at CT or MRI.
From the Departments of *Radiology and Biomedical Imaging and †Urology, University of California San Francisco, San Francisco, CA.
Received for publication April 13, 2012; accepted July 3, 2012.
Reprints: Fergus Coakley, MD, Department of Radiology Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, L340 Portland, OR 97239 (e-mail: firstname.lastname@example.org).
Dr Ziv was supported by T32 training grant 1 T32 EB001631 from the National Institute of Biomedical Imaging and Bioengineering.
The authors have no conflicts of interest.