This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.
A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.
Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.
In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.
From the Departments of *Diagnostic and Interventional Radiology, †Neurosurgery, and ‡Neurology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
Received for publication May 9, 2012; accepted July 3, 2012.
Reprints: Christian Mathys, MD, Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, D-40225, Düsseldorf, Germany (e-mail: email@example.com).
The authors did not receive funding for this study.
The authors have no conflicts of interest.