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Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31826801df
Neuroradiology

A Phantom Approach to Interscanner Comparability of Computed Tomographic Brain Perfusion Parameters

Mathys, Christian MD*; Rybacki, Konrad MD*; Wittsack, Hans-Jörg Dr. rer. nat.*; Lanzman, Rotem Shlomo MD*; Miese, Falk Roland MD*; Macht, Stephan MD*; Eicker, Sven MD; zu Hörste, Gerd Meyer MD; Antoch, Gerald MD*; Turowski, Bernd MD*

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Abstract

Objective: This study aimed to create a phantom, which allows reproducible computed tomography perfusion experiments, and to identify the influence of contrast bolus configuration, scan parameters, and scanner hardware on the calculation of perfusion parameters.

Methods: A discoid perfusion phantom with centrifugally directed flow was constructed. Brain parenchyma was simulated by inert polyoxymethylene spheres. Repeated measurements were performed with variations of the above-mentioned factors, and their effects on perfusion results were analyzed.

Results: Calculated flow values measured during experiments were reproducible and showed good correlation with the true flow (R = 0.995, P < 0.01). Tube voltage, injection rate of the contrast agent, the mathematical perfusion algorithm, and the hardware of the scanner hardware had a reproducible influence on calculated perfusion results.

Conclusions: In the long term, perfusion phantoms might be helpful in identifying hardware-specific and protocol-related factors of different computed tomography scanners to improve comparability of different scanners and scanning protocols.

© 2012 Lippincott Williams & Wilkins, Inc.

  

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