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Spontaneously Healed Asymptomatic Pulmonary Tuberculosis: Prevalence of Airflow Obstruction, and Correlation Between High-Resolution CT Findings and Pulmonary Function Tests

Lee, Ki Yeol MD, PhD*; Shin, Chol MD, PhD; Lee, Jung Bok PhD; Kang, Eun-Young MD, PhD*; Oh, Yu Whan MD, PhD*; Je, Bo Kyung MD, PhD*; Choo, Ji Young MD*; Yoon, Dae Wui MS§; Cho, Pyong-Kon PhD

Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182606b8d
Thoracic Imaging
Abstract

Rationale and Objectives: We investigated the relationships between spontaneously healed asymptomatic pulmonary tuberculosis (SHAPTB), airflow obstruction (AFO), and high-resolution computed tomography (HRCT) findings.

Materials and Methods: We selected 82 participants with SHAPTB diagnosed by interferon-γ release assay and 8044 with normal chest radiographs (CXR). We applied a CT scoring system for the extent of tuberculous sequelae to correlate the HRCT findings with pulmonary function test. We compared the AFO prevalence between subjects with and without SHAPTB.

Results: The subjects with SHAPTB diagnosed by interferon-γ release assay had a significantly higher prevalence of AFO (13.4% [11/82]) than those with normal CXR (7.4% [595/8044]). The important HRCT findings that correlated with AFO were the number of lung segments with TB sequelae and the CT score for emphysema.

Conclusion: The subjects with SHAPTB had a higher AFO prevalence than those with normal CXR, and the important HRCT findings correlated with AFO were the extent of tuberculous sequelae and emphysema.

Author Information

From the *Department of Radiology, Korea University Hospital, Seoul, Korea; †Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea; ‡Department of Clinical Epidemiology and Biostatics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; §Korea University College of Medicine, Ansan, Korea; and ∥Department of Radiological Science, Catholic University of Daegu, Daegu, Korea.

Received for publication March 11, 2012; accepted May 20, 2012.

Reprints: Ki Yeol Lee, MD, PhD, Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, 516 Gojan 1-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Korea (e-mail: cornerstonelee@gmail.com).

This study was supported by National Research Foundation of Korea Grant (R0807571).

The authors report no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.