Skip Navigation LinksHome > September/October 2012 - Volume 36 - Issue 5 > Multifocal Micronodular Pneumocyte Hyperplasia: Computed To...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e318264e404
Thoracic Imaging

Multifocal Micronodular Pneumocyte Hyperplasia: Computed Tomographic Appearance and Follow-Up in Tuberous Sclerosis Complex

Muzykewicz, David A. MD*; Black, Margaux E. BA*; Muse, Victorine MD; Numis, Adam L. MD*; Rajagopal, Jayaraj MD; Thiele, Elizabeth A. MD, PhD*; Sharma, Amita MD

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Objective: To characterize pulmonary nodules in patients with tuberous sclerosis complex (TSC) using computed tomography.

Methods: We retrospectively reviewed chest computed tomographic images of 73 patients with TSC (22 males and 51 females; mean ± SD age, 31.5 ± 13.2 years; range, 13.8–63.5 years).

Results: Multiple pulmonary nodules were identified in 42 (58%) of 73 patients (mean ± SD size, 6.6 ± 3.0 mm; range, 2–14 mm). Solid nodules were present in 11 (26%) of 42 patients, ground-glass nodules were present in 3 (7%) of 42 patients, and both solid and ground-glass nodules were present in 28 (67%) of 42 patients. The presence of multiple nodules was independent of sex and lymphangioleiomyomatosis. Follow-up images were available for 22 patients with multiple nodules (mean ± SD follow-up, 2.0 ± 1.1 years; range, 0.9–4.9 years), none of whom had change in nodule size or number.

Conclusions: Most men and women with TSC have multiple pulmonary nodules, which likely represent multifocal micronodular pneumocyte hyperplasia in the absence of known predisposing factors.

© 2012 Lippincott Williams & Wilkins, Inc.



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