Objective: To intraindividually compare a low–tube voltage, low–contrast material dose computed tomography (CT) reconstructed with iterative reconstruction (IR) algorithm at standard tube voltage reconstructed with filtered back projection (FBP) and standard–contrast material dose during liver dynamic CT.
Materials and Methods: Twenty-five patients with liver cirrhosis underwent 64-section multidetector CT. One hundred twenty kilovolt (peak) (kV[p]) with standard contrast material dose of 600 mg of iodine per kilogram (protocol A) and 80 kV(p) with low–contrast material dose of 450 mg of iodine per kilogram (protocol B) CT image sets were reconstructed by using FBP algorithm and that of using IR algorithm with a 60%/40% blend of IR-FBP reconstruction at 80-kV(p) image set (protocol C). Scans obtained during 3 hepatic phases were subjected to quantitative and qualitative analysis.
Results: The mean radiation dose and the contrast medium dose were significantly lower under protocols B and C than under protocol A. In all hepatic phases, all signal-to-noise and contrast-to-noise ratios were greater under protocol C than under other protocols at all anatomic sites. Qualitative analysis showed that image noise and diagnostic acceptability were significantly higher under protocol C.
Conclusion: In all hepatic phases, a low–tube voltage, low–contrast material dose CT with IR algorithm yielded better contrast enhancement and image quality than a standard tube voltage, standard contrast material dose CT with FBP in thin adult patients.