Skip Navigation LinksHome > March/April 2012 - Volume 36 - Issue 2 > Idiopathic Nonspecific Interstitial Pneumonia: Changes in H...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31823ed437
Thoracic Imaging

Idiopathic Nonspecific Interstitial Pneumonia: Changes in High-Resolution Computed Tomography on Long-Term Follow-Up

Kim, Mi-Young MD, PhD*; Song, Jin Woo MD; Do, Kyung-Hyun MD*; Jang, Se Jin MD; Colby, Thomas V. MD§; Kim, Dong Soon MD

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Abstract

Objective: This study aimed to assess the change in findings of nonspecific interstitial pneumonia (NSIP) from high-resolution computed tomography (HRCT) on long-term follow-up (median, 38 months).

Materials and Methods: A retrospective review of changes in HRCT in 68 patients with NSIP (fibrotic progression, 61) with follow-up HRCT of at least 1-year interval was conducted.

Results: Follow-up HRCT findings showed a decreased extent of ground-glass opacity and consolidation, with increased honeycombing, traction bronchiectasis, and architectural distortion (all P < 0.05). Radiological improvement was seen in 36%, stability was seen in 23%, and fibrotic progression was seen with recurrence in 13% and without recurrence in 28%. In 3 patients (4.9%), HRCT converted to a definite usual interstitial pneumonia pattern. Honeycombing and reticulation were independent predictors for mortality in fibrotic NSIP (P < 0.01).

Conclusions: Although most of the follow-up HRCT scans showed improvement in the extent of ground-glass opacity and consolidation, approximately one third showed fibrotic progression or recurrence, with transition from NSIP to definite usual interstitial pneumonia pattern.

© 2012 Lippincott Williams & Wilkins, Inc.

 

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