Skip Navigation LinksHome > March/April 2012 - Volume 36 - Issue 2 > Idiopathic Nonspecific Interstitial Pneumonia: Changes in H...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31823ed437
Thoracic Imaging

Idiopathic Nonspecific Interstitial Pneumonia: Changes in High-Resolution Computed Tomography on Long-Term Follow-Up

Kim, Mi-Young MD, PhD; Song, Jin Woo MD; Do, Kyung-Hyun MD; Jang, Se Jin MD; Colby, Thomas V. MD; Kim, Dong Soon MD

Supplemental Author Material
Collapse Box

Abstract

Objective: This study aimed to assess the change in findings of nonspecific interstitial pneumonia (NSIP) from high-resolution computed tomography (HRCT) on long-term follow-up (median, 38 months).

Materials and Methods: A retrospective review of changes in HRCT in 68 patients with NSIP (fibrotic progression, 61) with follow-up HRCT of at least 1-year interval was conducted.

Results: Follow-up HRCT findings showed a decreased extent of ground-glass opacity and consolidation, with increased honeycombing, traction bronchiectasis, and architectural distortion (all P < 0.05). Radiological improvement was seen in 36%, stability was seen in 23%, and fibrotic progression was seen with recurrence in 13% and without recurrence in 28%. In 3 patients (4.9%), HRCT converted to a definite usual interstitial pneumonia pattern. Honeycombing and reticulation were independent predictors for mortality in fibrotic NSIP (P < 0.01).

Conclusions: Although most of the follow-up HRCT scans showed improvement in the extent of ground-glass opacity and consolidation, approximately one third showed fibrotic progression or recurrence, with transition from NSIP to definite usual interstitial pneumonia pattern.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.

  

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.