Objective: The objective of the study was to determine the value of addition of hepatobiliary phase to dynamic gadobenate dimeglumine (Gd-BOPTA)–enhanced imaging for the detection of focal liver lesions (nodules with diameter ≤3.0 cm).
Methods: Routine nonenhanced magnetic resonance images were obtained in 25 patients with focal liver lesions suggested by ultrasonography and/or computed tomography.
T1-weighted dynamic gradient-echo images were acquired immediately and 100 minutes after bolus injection of Gd-BOPTA. The number of the lesions detected by T1-weighted imaging, T2-weighted imaging, diffusion-weighted imaging, dynamic contrast-enhanced, and delayed hepatobiliary-phase imaging was counted, respectively. Contrast-to-noise ratios were measured for all the sequences including delayed hepatobiliary-phase imaging. The signal intensity and morphologic features of liver parenchyma and lesions were recorded and analyzed.
Results: There were 7 patients with hepatocellular carcinomas, 6 with hemangiomas, 7 with metastases, and 5 with cholangiocarcinomas. The delayed hepatobiliary-phase imaging showed a homogeneous enhancement of liver parenchyma and distinctive enhancement features of focal liver lesions. The delayed hepatobiliary-phase imaging was better than diffusion-weighted imaging for the detection of focal liver lesions (P < 0.05).
Conclusion: The addition of hepatobiliary-phase imaging to Gd-BOPTA–enhanced dynamic imaging increased the sensitivity and accuracy for the detection of focal hepatic lesions.
From the *Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Sichuan, China; and †Department of Radiology, University of Southern California Keck School of Medicine.
Received for publication July 22, 2011; accepted October 18, 2011.
Reprints: Yong Du, MD, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63# Wen Hua Lu, Nanchong, Sichuan 637000, China (e-mail: email@example.com).
The authors report no conflicts of interest.