Skip Navigation LinksHome > January/February 2012 - Volume 36 - Issue 1 > Gadobenate Dimeglumine–Enhanced Liver Magnetic Resonance Ima...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31823dc139
Abdominal Imaging

Gadobenate Dimeglumine–Enhanced Liver Magnetic Resonance Imaging: Value of Hepatobiliary Phase for the Detection of Focal Liver Lesions

Fu, Guo-li MD; Du, Yong MD; Zee, Chi-shing MD; Yang, Han-feng MD; Li, Yang MD; Duan, Ru-gang MD; Zeng, Nan-lin MD; Xiao, Dong-Mei MD

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Objective: The objective of the study was to determine the value of addition of hepatobiliary phase to dynamic gadobenate dimeglumine (Gd-BOPTA)–enhanced imaging for the detection of focal liver lesions (nodules with diameter ≤3.0 cm).

Methods: Routine nonenhanced magnetic resonance images were obtained in 25 patients with focal liver lesions suggested by ultrasonography and/or computed tomography.

T1-weighted dynamic gradient-echo images were acquired immediately and 100 minutes after bolus injection of Gd-BOPTA. The number of the lesions detected by T1-weighted imaging, T2-weighted imaging, diffusion-weighted imaging, dynamic contrast-enhanced, and delayed hepatobiliary-phase imaging was counted, respectively. Contrast-to-noise ratios were measured for all the sequences including delayed hepatobiliary-phase imaging. The signal intensity and morphologic features of liver parenchyma and lesions were recorded and analyzed.

Results: There were 7 patients with hepatocellular carcinomas, 6 with hemangiomas, 7 with metastases, and 5 with cholangiocarcinomas. The delayed hepatobiliary-phase imaging showed a homogeneous enhancement of liver parenchyma and distinctive enhancement features of focal liver lesions. The delayed hepatobiliary-phase imaging was better than diffusion-weighted imaging for the detection of focal liver lesions (P < 0.05).

Conclusion: The addition of hepatobiliary-phase imaging to Gd-BOPTA–enhanced dynamic imaging increased the sensitivity and accuracy for the detection of focal hepatic lesions.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.



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