Skip Navigation LinksHome > January/February 2012 - Volume 36 - Issue 1 > Dynamic Contrast-Enhanced Magnetic Resonance Imaging–Derived...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31823f6c59

Dynamic Contrast-Enhanced Magnetic Resonance Imaging–Derived kep as a Potential Biomarker of Matrix Metalloproteinase 9 Expression in Patients With Glioblastoma Multiforme: A Pilot Study

Awasthi, Rishi MSc*; Pandey, Chandra M. PhD; Sahoo, Prativa MSc; Behari, Sanjay MCh§; Kumar, Vijendra MS§; Kumar, Shaleen MD; Misra, Shagun MD; Husain, Nuzhat MD; Soni, Priyanka MSc; Rathore, Ram K.S. PhD; Gupta, Rakesh Kumar MD*

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Objective: To look for the association of tissue matrix metalloproteinase 9 (MMP-9) expression with dynamic contrast-enhanced magnetic resonance imaging and to see whether these can prognosticate patients with glioblastoma multiforme (GBM).

Methods: Forty-seven patients with GBM underwent dynamic contrast-enhanced magnetic resonance imaging to look for association of its indices with tissue MMP-9 expression using Pearson correlation. Kaplan-Meier survival analysis was performed to study the survival pattern for low-, medium-, and high-tissue MMP-9 expression and kep values.

Results: Among perfusion indices, kep, ktrans, and ve significantly correlated with MMP-9 expression. Matrix metalloproteinase 9 expression was found to be best estimated by kep using a quadratic model. The 1-year survival in low-, medium-, and high-tissue MMP-9 and kep groups were 59%, 45%, and 7%, and 59%, 33%, and 15%, respectively.

Conclusion: The association of kep and MMP-9 expression with survival suggests that kep may be used as imaging biomarker of GBM progression and its prognostication.

© 2012 Lippincott Williams & Wilkins, Inc.



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