Skip Navigation LinksHome > November/December 2011 - Volume 35 - Issue 6 > Investigation of a Logistic Model for T2* Dynamic Susceptibi...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e3182372a12
Original Article

Investigation of a Logistic Model for T2* Dynamic Susceptibility Contrast Magnetic Resonance Imaging (dscMRI) Perfusion Studies

Wardlaw, Graeme M. PhD*†; Wong, Raimond MD, FRCPC; Boylan, Colm MB, BCh, MRCP, FRCR§; Rebello, Ryan MD, FRCPC§; Noseworthy, Michael D. PhD, PEng*†§∥¶

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Abstract: There are a number of T1- and T2-based dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic modeling approaches to study cancer microvasculature. Alternatively, model-free approaches offer an easy, quantitative assessment of microcirculation. In this work, we investigate a 6-parameter model-free approach applied to a T2*-weighted echo-planar imaging bolus response curve. We tested this new approach on a small cohort of patients with clinically diagnosed primary rectal carcinoma before adjuvant chemoradiotherapy and surgical excision. Comparison with healthy muscle tissue shows that logistic parameters P1/P2, P4, and P5 offer good discrimination between tumor and healthy tissue. Bolus response logistic parameters P4 and P5 have been implicated in previous T1-based works as being important in the assessment of cancer malignancy. Further comparison of T2* parameters with signal attenuation amplitude (maximum signal drop) and percentage baseline signal loss also corroborates the models’ ability to quantify the microenvironment.

© 2011 Lippincott Williams & Wilkins, Inc.



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