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Computed Tomography and Magnetic Resonance Features of Gliosarcoma: A Study of 54 Cases

Zhang, Bi-Yun MM*; Chen, Hong MD; Geng, Dao-Ying MD*; Yin, Bo MD*; Li, Yu-Xin MD*; Zhong, Ping MD; Wu, Jin-Song MD; Wang, Xiao-Qiang PhD*

Journal of Computer Assisted Tomography: November/December 2011 - Volume 35 - Issue 6 - p 667–673
doi: 10.1097/RCT.0b013e3182331128
Original Article

Objective: To investigate the features of pathologically confirmed gliosarcomas using computed tomography (CT) and magnetic resonance (MR) imaging.

Methods: We retrospectively reviewed the cross-sectional CT and MR images of 54 patients (37 males and 17 females; mean age, 44.5 years; range, 13–74 years) with gliosarcomas confirmed by histopathology.

Results: Across all patients, there were 59 lesions. On nonenhanced CT and MR images, tumors were predominantly inhomogeneous. On the postcontrast CT and MR images, 50 (84.7%) irregular lesions had thick walls with a strong rim- and ringlike enhancement, whereas the remaining 9 (15.3%) round or oval lesions had even thin walls with an enhanced peripheral ring. Magnetic resonance spectroscopy showed increased choline and lactate values, along with decreased N-acetylaspartate and creatine values. On diffusion-weighted imaging, the tumor was slightly or markedly hyperintense compared with the white matter.

Conclusion: A well-demarcated mass located peripherally, with rimlike or ring enhancement, is a common presentation of gliosarcoma on CT and MR images. In addition, magnetic resonance spectroscopy and diffusion-weighted imaging can be used to make a differential diagnosis.

From the Departments of *Radiology, †Neuropathology, and ‡Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Received for publication June 1, 2011; accepted August 11, 2011.

Reprints: Xiao-Qiang Wang, PhD, or Dao-Ying Geng, MD, Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China (e-mail:,

The authors did not receive any funding for research for this manuscript.

The authors have no conflict of interest.

Bi-Yun Zhang, MM, and Hong Chen, MD, contributed equally to this work.

© 2011 Lippincott Williams & Wilkins, Inc.