Skip Navigation LinksHome > September/October 2011 - Volume 35 - Issue 5 > Simultaneous Measurement of Left and Right Ventricular Volum...
Journal of Computer Assisted Tomography:
doi: 10.1097/RCT.0b013e31822abbcd
Cardiovascular Imaging

Simultaneous Measurement of Left and Right Ventricular Volumes and Ejection Fraction During Dobutamine Stress Cardiovascular Magnetic Resonance

Mandapaka, Sangeeta MD*; Hamilton, Craig A. PhD†; Morgan, Timothy M. PhD‡; Hundley, William Gregory MD*§

Collapse Box

Abstract

Objective: During cardiovascular stress, if right ventricular (RV) stroke volume exceeds left ventricular (LV) stroke volume, then a large volume of blood is displaced into the pulmonary circulation that may precipitate pulmonary edema. We sought to determine the metrics by which cardiovascular magnetic resonance (CMR) could measure simultaneous displacement of RV and LV stroke volumes during dobutamine stress.

Methods: Thirteen healthy subjects (5 women) aged 53 ± 10 years without medical conditions and taking no medications underwent 2 CMR examinations at 1.5 T separated by 4 to 8 weeks in which RV and LV stroke volumes were determined during intravenous dobutamine and atropine infused to achieve 80% of the maximum predicted heart rate response for age.

Results: The RV and LV stroke volumes were highly correlated at each level of stress (rest: r = 0.98, P = 0.007; low stress: r = 0.87, P = 0.001; and peak stress: r = 0.88, P = 0.001), and the mean difference in SV at each level of stress (rest, low stress, and peak stress was 0 to 2 mL on examinations 1 and 2.

Conclusions: Simultaneous change in right and left ventricular stroke volumes can be assessed in a highly reproducible manner throughout the course of dobutamine CMR stress administered to achieve 80% of maximum predicted heart rate response for age. This technology may help identify discrepancies in RV and LV stroke volumes during cardiovascular stress that are associated with the development of pulmonary edema.

© 2011 Lippincott Williams & Wilkins, Inc.

 

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.